ZX-55117-96 | High-Sensitivity Thyroxine (T4) ELISA Kit
Thyroid hormones produced and released by thyroid gland are tyrosine-based hormones and consist of two hormones: Thyroxine (T4) which contains 4 atoms of iodine, and triiodothyronine (T3), which has 3 atoms of iodine. These hormones are primarily responsible for regulation of metabolism. Due to their structure deficiency in iodine leads to decreased production of T3 and T4, which enlarges the thyroid tissue and will cause the disease named goiter. Thyroxine is the main hormone produced by the thyroid gland and the major form of thyroid hormone in the blood (The blood ratio of T4 to T3 is approximately 20 to 1). The hypothalamus and the pituitary gland (located in the brain) are involved in controlling the thyroid gland and its hormones via Thyroid stimulating hormone (TSH) modulation. Thyroid hormones are very critical for the human body and regulate some of developmental, metabolic, and neural activities in the body. Approximately 20% of T3 is produced in the thyroid gland; the rest of T3 however, is generated by the deiodination of T4 in peripheral tissues. Although circulating levels of T4 are much higher than T3 levels, T3 is more metabolically active (3-4 times more than T4).
Circulating thyroid hormones are mostly bound to carrier proteins (e.g. thyroid- binding globulin [TBG], prealbumin and albumin); the biologically active form of T3 is however, the unbound (free) T3. Although both T3 and T4 are bound to TBG, T4 is bound more firmly than T3. Under-production of thyroxine by the thyroid gland leads to hypothyroidism. This condition is either due to naturally underactivity of thyroid gland or because of radioiodine therapy or surgery for an overactive gland.
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