Caffeic Acid Phenethyl Ester (CAPE) or the ester of caffeic acid and phenethyl alcohol is a bioactive component of honeybee hive propolis extract, which has anti-inflammatory, antitumor, antiviral, antibacterial, antifungal and immunostimulatory activities. It inhibits the activation of nuclear transcription factor NF-κB and suppresses p70S6K and Akt-driven signaling pathways. Moreover, through activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells.
Catalog Number: ZXB-06-103
CAS Number: 104594-70-9
Synonyms: Phenethyl 3,4-Dihydroxycinnamate; CAPE
Molecular Weight: 284.31
PubChem Chemical ID: 5281787