Thymidine (dT) or pyrimidine deoxyriboside (deoxynucleoside) is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose which is used to synthesize DNA and the T-loop of transfer RNA upon sequential phosphorylation to deoxythymidine triphosphate (dTTP). As a constituent of DNA, thymidine pairs with deoxyadenosine (A) in the structure of double-stranded DNA.
Thymidine kinase (TK, EC 184.108.40.206) is an enzyme that catalyses the phosphorylation of deoxythymidine to deoxythymidine monophosphate with a phosphate derived from ATP. Hence, dT may be used to study the distribution, specificity and kinetics of a family of thymidine kinase(s). It derives from a thymine and has a role as a metabolite (human metabolite, Escherichia coli metabolite and mouse metabolite). It is also used as a synchronizer of the cells in S phase of mitosis.
Catalog Number: ZXB-06-161
CAS Number: 50-89-5
Synonyms: deoxythymidine, 2′-Deoxythymidine
Molecular Weight: 242.23
PubChem Chemical ID: 5789