ZX-55115-96 | Triiodothyronine (T3) ELISA Kit
Thyroid hormones produced and released by thyroid gland consist of two hormones: Thyroxine, which contains 4 atoms of iodine (T4), and triiodothyronine (T3), which has 3 atoms of iodine. The hypothalamus and the pituitary gland (located in the brain) are involved in controlling the thyroid gland and its hormones. Thyroid hormones are very critical for the human body and regulate some of developmental, metabolic, and neural activities. Approximately 20 percent of T3 is produced in the thyroid gland; the rest of T3 however, is generated by the deiodination of T4 to T3 in peripheral tissues. Although circulating levels of T4 are much higher than T3 levels, T3 is more metabolically active (3-4 times more than T4), it is worth noting however, due to shorter half-life, T3 effect is briefer.
Circulating thyroid hormones are mostly bound to carrier proteins (e.g. thyroid- binding globulin [TBG], prealbumin and albumin); the biologically active form of T3 is however, the unbound (free) T3. Although both T3 and T4 are bound to TBG, T4 is bound more firmly than T3. Total T3 consists of both the bound and unbound fractions.
In hyperthyroidism, also known as overactive thyroid, the level of both T4 and T3 are usually increased, however, a small subgroup of the patients shows a pattern (T3 thyrotoxicosis) with elevated free T3 but normal free T4. hypothyroidism patients oppositely showed decreased levels of both T4 and T3.
Use: Measure Triiodothyronine (T3) in 2.5 hours
Sample: Extracted Serum and Plasma, Urine, Dried Fecal Extracts, and Tissue Culture Media
Sample/Kit: 39 in Duplicate
Sensitivity: 37.4 pg/mL
Stability: 4˚C | T3 Standard and T3 Conjugate in -20°C
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