Aldosterone (C₂₁H₂₈O₃) is a mineralocorticoid hormone produced by aldosterone synthase enzyme (CYP11B2) in the zona glomerulosa of the adrenal cortex. It controls the sodium‐potassium balance via the unidirectional salt reabsorption in a variety of tissues and glands including kidney and colon. Aldosterone, together with Renin and Angiotensin, create a hormone system called Renin-Angiotensin-Aldosterone system (RAAS). RAAS regulates the blood stream in kidney in response to rehydration due to a reduced blood pressure, or a significant drop in blood volume after a hemorrhage or serious injury. It also indirectly affects the blood’s pH and electrolyte levels. Being dependent on age and body position, peripheral Aldosterone levels are typically less than 300 pg/mL in a normal upright adult.

Aldosterone measurement is useful in the diagnosis of primary aldosteronism (i.e., adrenal adenoma or carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome). The Renin-Angiotensin system is the primary regulator of the synthesis and secretion of Aldosterone. Increased concentrations of potassium in the plasma may directly stimulate adrenal production of the hormone. The ZellX® Aldosterone Chemiluminescent Immunoassay (CLIA) kit has been designed to quantitatively measure the amount of Aldosterone present in extracted serum, plasma, urine, saliva, extracted dried fecal samples, as well as tissue culture media samples. To measure Aldosterone using colorimetric ELISA use our Aldosterone ELISA Kit (Cat. No. ZX-55111-96).