ZX-55108-96 | High Sensitivity Estradiol (Serum & Plasma) ELISA Kit
Estradiol (C18H24O2), also known as E2, is a major female sex hormone (strongest estrogen) which regulates menstrual reproductive cycles as well as the estrous cycle. It is a key regulator of growth, differentiation, and function in a wide array of tissues, including the male and female reproductive tracts, mammary gland, brain, skeletal and cardiovascular systems. E2 has two distinct intracellular receptors; ERα and ERβ which are mediating the main biological functions of E2. ERα and ERβ are encoded by unique genes possessing the functional domain characteristics of the steroid/thyroid hormone superfamily of nuclear receptors. ERα, as the predominant form, is expressed in the breast, uterus, cervix, and vagina., whereas ERβ exhibits a more limited pattern and is primarily expressed in the ovary, prostate, testis, spleen, lung, hypothalamus, and thymus. Estradiol also influences bone growth, brain development and maturation, and food intake, and it is also critical in maintaining organ functions during severe trauma. In liver, Estradiol is conjugated to sulfate and glucuronide derivatives and excreted. Conversion to less-active estrogens, such as Estrone and Estriol (the major urinary metabolite) leads to deactivation of Estradiol.
The ZellX® high sensitivity Estradiol ELISA kit is a competitive assay designed to quantitatively measure Estradiol and its metabolites present in serum and plasma. For analyzing Estradiol in urine, extracted dried fecal samples, and tissue culture media use our Estradiol ELISA Kit Cat. No. ZX-55107-96.
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